Expression of Ki67 and CerbB-2 in Gall Bladder, Oesophageal, Small Intestinal and Colorectal Adenocarcinomas: A Study from a Tertiary Care Hospital in Western U.P.

Introduction: Gall bladder cancer is the commonestbiliary tract malignancy with poor prognosis. Oesophagealadenocarcinomas are aggressive with very poor survival.Adenocarcinomas of small intestine are rare, in comparisonto colorectal carcinomas. We studied the expression of twocommonly studied immunohistochemical markers Ki67 andCerbB-2 in gall bladder and gastrointestinal carcinomas, tofind out their prognostic significance.Material and Methods: Histopathologically confirmed casesof adenocarcinomas of gall bladder (19 cases), oesophagus(3 cases), small intestine (3 cases) and colorectal region (8cases) were included. Formalin fixed paraffin embeddedtissue blocks were retrieved and sections were studiedimmunohistochemically for expression of Ki67 and CerbB-2.Tumors of all stages and grades were studied.Results: Our study revealed a significantly high Ki67in neoplastic glands of gall bladder, oesophageal, smallintestinal and colorectal adenocarcinomas as comparedto the non neoplastic areas. The Ki67 labelling index washigher in moderately and poorly differentiated areas as wellas mucinous and signet ring type adenocarcinomas. Therewas no relation with stage/depth of tumor invasion. CerbB-2was significantly overexpressed in gall bladder and colorectaladenocarcinomas. Expression was higher in advanced stageand greater depth of invasion. There was no associationwith tumor grade or type. In esophageal and small intestineadenocarcinomas, expression was not related to either tumorstage or grade.Conclusion: A panel of Ki67 and CerbB-2 in gastrointestinaland biliary tract malignancies may correlate well with differentprognostic indicators in these malignancies, like tumor stage,histologic type and grade.

Lipofibromatous hamartoma of the digital branches of the median nerve presenting as carpal tunnel syndrome: A rare case report with review of the literature.

Lipofibromatous hamartoma (LFH) is a rare, benign fibrofatty tumor composed of a proliferation of mature adipocytes within peripheral nerves, which form a palpable neurogenic mass. It affects the median nerve in 66–80% of cases, causing pain and sensory and motor deficits in the affected nerve distribution. Patients typically present with gradually enlarging nontender lesions in the distribution of the affected nerve. The lesion is also seen to be associated with macrodactyly. The pathophysiology of LFH is unknown. Treatment of LFH is based on symptoms of the condition. Histopathology is characteristic. We present a case of young male diagnosed as lipofibromatous hamartoma of the median nerve involving the right index finger. The case is presented due to its rarity.

Subconjunctival Cysticercosis: A Case Report.

Cysticercus cellulosae occurs worldwide, mainly in poor regions with insufficient sanitary conditions. Ocular cysticercosis develops from Taenia solium larvae in ocular structures. The eye could be the prime location for such parasitic infection because of its rich vascularization and almost all structures such as orbit, extraocular muscles, conjunctiva, anterior segment, and posterior segment can be involved. Diagnosis is usually made on history, clinical examination, radiological findings, and histopathology. We report a case of a 13-year-old girl who presented with a subconjunctival cyst. It was diagnosed as implantation cyst based on history and clinical findings. Complete surgical excision was done. On histopathological examination, ocular cysticercosis was confirmed. The patient was given oral albendazole and prednisolone, post-operatively. The ocular cysticercosis is an oft-reported problem in North India. Surgical excision is the treatment of choice. Inaccessible cysts are best treated with oral albendazole along with prednisolone.

Inadequate Nasogastric Drainage In Acute Intestinal Obstruction (A Rare Cause With Literature Review).

Abstracts: Background: Nasogastric aspiration is bedside procedure in surgical wards. Amount and type of nasogastic drainage is helpful in establishing conditions such as intestinal obstruction and its level. Knotted nasogastric tube is rarely reported in literature. In our case of intestinal obstruction this rare condition led to a diagnostic dilemma. Through this we want to highlight that in patients with intestinal obstruction and inadequate nasogastric tube drainage, possibility of this rare complication should be thought of.

Rupture of Gravid Bicornuate Uterus as a Rare Cause of Acute Abdomen: A Case Report.

Pregnancy in rudimentary horn of uterus is a rare and fatal complication of mullerian duct anomaly. We report one such female presenting with acute abdomen and amenorrhea to highlight the importance of keeping this in differential diagnosis of acute abdomen of women of child bearing age.